地尔硫缓释片与硝苯地平控释片治疗心率增快的高血压病人的疗效

目的 :观察比较地尔硫与硝苯地平对伴有心率增快的高血压病人在降低血压和心率上的疗效。方法 :地尔硫组 37例 (男性 2 1例 ,女性 16例 ;年龄 5 0a±s11a)接受地尔硫缓释片 180mg ,po ,qd× 4wk。硝苯地平组 38例 (男性 2 3例 ,女性15例 ;年龄 5 1a± 10a)接受硝苯地平控释片 2 0mg ,po ,bid× 4wk。结果 :2组治疗后BP均有明显下降 (P <0 .0 1)。SBP :地尔硫组从 (2 2 .7± 1.6)kPa下降至 (18.0± 1.3)kPa ;硝苯地平组从 (2 3.8± 1.5 )kPa下降至 (17.6± 1.3)kPa ,组间比较 (P>0 .0 5 )。DBP :地尔硫组从 (12 .7± 1.3)kPa下降至 (10 .4± 1.5 )kPa ,硝苯地平组的从 (12 .8±1.6)kPa下降至 (10 .8± 2 .3)kPa ,2组间差异无显著意义 (P >0 .0 5 )。地尔硫组治疗后HR从 (90± 10 )次·min- 1下降至 (71± 8)次·min- 1(P <0 .0 1) ;而硝苯地平组由治疗前 (90± 9)次·min- 1至治疗后的 (93± 8)次·min- 1;组间差异明显。结论 :地尔硫对伴有心率增快的高血压病人兼有降低血压和心率的作用 ,优于硝苯地平。

Diltiazem-sustained released tablet vs nifedipine-controlled released tablet in treating essential hypertension with high heart rate

AIM: To observe and compare the efficacies between diltiazem and nifedipine on declining blood pressure and heart rate in patients of hypertension with high heart rates. METHODS:Diltiazem group(group D) of 37 patients(M 21, F 16; age 50 a± s 11 a) received diltiazem SR 180 mg, po , qd for 4wk. Nifedipine group(group N) of 38 patients(M 23, F 15; age 51 a±10 a) received nifedipine CR 20 mg, po , bid for 4 wk. RESULTS:Blood pressure was declined obviously in both two groups after treament( P <0.01). SBP declined from(22.7±1.6) kPa to (18.0±1.3) kPa in group D; but from (23.8±1.5) kPa to (17.6±1.3) kPa in group N. The latter appeared superior to the former ( P > 0.05 ). DBP declined from (12.7±1.3) kPa to (10.4± 1.5 ) kPa in group D, which appeared superior to that of group N from (12.8±1.6) kPa to (10.8±2.3) kPa) ( P >0.05)]. Heart rate declined from (90±10)·min -1 to (71±8)beat·min -1 in group D( P < 0.01 ), but which was still (93±8)beat·min -1 in group N. There was a significant difference between two groups( P <0.01). CONCLUSION: Diltiazem has efficacies both in decling BP and HR. It is superior to nifedipine on the treatment of patients of hyperthension with high heart rate.