抗VEGF药物治疗增殖期糖尿病性视网膜病变的疗效观察

目的观察增殖期糖尿病性视网膜病变(PDR)患者接受抗血管内皮生长因子(VEGF)药物治疗的临床疗效。方法75例(104眼)PDR患者,根据治疗方式不同分为对照组21例(42眼)]和观察组54例(62眼)]。对照组患者行单纯激光治疗,观察组患者行抗VEGF药物治疗。对比两组患者治疗效果、新生血管消退情况以及治疗前后最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)、视网膜新生血管渗漏面积(RNV)。结果治疗前,两组患者BCVA、RNV、CMT水平比较差异无统计学意义(P>0.05);治疗后,两组患者BCVA、RNV、CMT水平均优于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组患者新生血管消退率92.59%高于对照组的66.67%,差异具有统计学意义(P<0.05)。观察组治疗总有效率为96.30%,显著高于对照组的76.19%,差异具有统计学意义(P<0.05)。结论PDR患者接受抗VEGF药物治疗,可有效促进视网膜新生血管消退,改善视功能,临床疗效确切。

Observation of the effect of anti-VEGF drugs on the treatment of proliferative diabetic retinopathy

Objective To observe the clinical efficacy of anti-vascular endothelial growth factor(VEGF)drugs on the treatment of patients with proliferative diabetic retinopathy(PDR).Methods A total of 75 PDR patients(104 involved eyes)were divided into control group21 cases(42 eyes)]and observation group54 cases(62 eyes)]according to different treatment methods.Patients in the control group received laser treatment alone,and patients in the observation group received anti-VEGF drug treatment.The therapeutic effect,regression of neovascularization and best corrected visual acuity(BCVA),center macular thickness(CMT),retinal neovascularization(RNV)before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in levels of BCVA,RNV and CMT between the two groups(P>0.05).After treatment,the levels of BCVA,RNV and CMT of the two groups were better than those before treatment,and the observation group was better than the control group.All the difference was statistically significant(P<0.05).The regression rate of neovascularization 92.59%of the observation group was higher than 66.67%of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 96.30%,which was significantly higher than 76.19%of the control group,and the difference was statistically significant(P<0.05).Conclusion Anti-VEGF drug treatment has a definite clinical effect on PDR patients,which can effectively promote the regression of retinal neovascularization,improve visual function.