Autonomic dysfunction is associated with high mobility group box-1 levels in patients after acute myocardial infarction |
| |
| Authors: | Francesco Giallauria Plinio Cirillo Rosa Lucci Mario Pacileo Mariantonietta D’Agostino Paola Maietta Alessandra Vitelli Massimo Chiariello Carlo Vigorito |
| |
| Affiliation: | 1. Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, University of Naples “Federico II”, Naples, NA 80131, Italy;2. National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch at Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA;3. Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Division of Cardiology, University of Naples “Federico II”, Naples, NA 80131, Italy;1. Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany;2. Chair for Bioinformatics and Information Mining, University of Konstanz, Konstanz, Germany;1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;2. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;3. Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;1. Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England;2. Third Respiratory Medicine Department, Sismanogleion General Hospital, Athens, Greece;3. First Respiratory Medicine Department, University of Athens, Sotiria Hospital, Athens, Greece;4. Division of Respiratory Diseases I, National and Kapodistrian University of Athens, Athens, Greece;1. DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coruña, A Coruña, Spain;2. Department of Cell and Molecular Biology, Universidade da Coruña, A Coruña, Spain;3. Gerontology Research Group, Universidade da Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, A Coruña, Spain;4. Biocenter, Innsbruck Medical University, Innsbruck, Austria;1. Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Oman;2. Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia;3. Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia;4. College of Medicine and Health Sciences, Sultan Qaboos University, Oman;5. Neuropharmacology group, MND and Neurodegenerative diseases Research Centre, Macquarie University, NSW, Australia;1. College of Pharmaceutical Science, Soochow University, Suzhou 215123, China;2. National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677, United States;3. College of Chemical, Biological and Material Engineering, Suzhou Science and Technology University, Suzhou 215009, China |
| |
| Abstract: | BackgroundHigh mobility group box-1 (HMGB1) protein, a critical mediator of inflammatory processes, is a novel predictor of adverse post-infarction clinical outcomes, being involved in the healing process after MI. Heart rate recovery (HRR), a marker of autonomic function defined as the fall in heart rate during the first minute after exercise, is a powerful predictor of mortality in post-infarction patients. The present study was designed to test the hypothesis that HMGB1 is associated with autonomic dysfunction in post-infarction patients.MethodsSixty-seven consecutive patients (mean age 59.3 years, 84% males) recovering from acute MI were included in the study protocol. All patients underwent Doppler-echocardiography, cardiopulmonary exercise and HMGB1 assay.ResultsHMGB1 levels were inversely correlated with peak oxygen consumption (VO2peak) (r = ?0.449, P < 0.001), with left ventricular ejection fraction (LVEF) (r = ?0.360, P = 0.003), and with HRR (r = ?0.387, P < 0.001). In a linear regression analysis adjusted for multiple confounders, we found a significant inverse association between HMGB1 levels and HRR independent of age, gender, body mass index, VO2peak, slope of increase in ventilation over carbon dioxide output (VE/VCO2slope), and presence of diabetes (β = ?0.377, P = 0.034).ConclusionsThis study provided the first evidence for a significant association between increased HMGB1 levels and autonomic dysfunction expressed by post-exercise slower HRR in post-infarction patients. The prognostic implication of such association needs to be explored as well as whether HMGB1 could represent a valid marker for risk stratification either during the acute phase or long-term after MI. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
