基于中西医临床病症特点血栓闭塞性脉管炎动物模型分析

基于血栓闭塞性脉管炎的临床病症特点,通过查阅相关文献,整理分析并建立血栓闭塞性脉管炎的西医诊断标准与中医辨证标准,总结血栓闭塞性脉管炎动物模型的造模方法、造模对象、模型优缺点.分析其与中西医临床病症特点的吻合度,总结发现血栓闭塞性脉管炎动物模型与西医临床病症吻合度较高,与中医寒湿阻络证和热毒伤阴证吻合度较高,与湿热毒盛...

Analysis on Animal Models of Thromboembolic Vasculitis Based on Clinical Symptoms in Traditional Chinese and Western Medicine

Based on the clinical characteristics of thromboembolic vasculitis,the diagnostic criteria in western medicine and the dialectical standard in traditional Chinese medicine(TCM) were analyzed and established by consulting relevant literature,and the modeling method,modeling objects as well as modeling advantages and disadvantages for the animal models of thromboembolic vasculitis were summarized in this paper.By analyzing its coincidence with the characteristics of clinical symptoms in traditional Chinese and western medicine,it was found that the animal model of thromboembolic vasculitis had a higher degree of coincidence with the clinical symptoms in western medicine,as well as cold and dampness blocking collaterals syndrome and heat toxin injury yin syndrome in TCM,but lower degree of coincidence with damp-heat toxin syndrome and Qiblood deficiency syndrome. There is no animal model consistent with blood stasis syndrome. The pathological and hemorheological indexes(blood viscosity,erythrocyte sedimentation rate)were the most common indexes.Compared with a large number of cases reported in clinical treatment of thromboangiitis obliterans,the experimental research was relatively weak. It is the focus of future research to establish a reasonable model to judge the quantitative standard,and to establish the animal model with higher coincidence degree with TCM syndrome.