玫瑰痤疮面部潮红与红斑新认识

【摘要】 持续型面中部红斑与潮红是玫瑰痤疮最常见的临床表现，但对其病理机制了解甚少，并缺乏高证据等级临床研究支持。本文结合国内外研究进展及临床经验，强调将面部潮红与红斑作为独立的临床表型进行研究探讨的必要性，认为精神压力、焦虑和/或抑郁可能是其发病的使动环节。由精神因素出发，探索玫瑰痤疮面部潮红及红斑相关神经炎症与皮肤免疫及血管的关系具有潜在的临床意义。

New insights into facial flushing and erythema in rosacea

Persistent centrofacial erythema with transient flushing is the most common clinical manifestation of rosacea.However,its pathological mechanisms are poorly understood,and there is a lack of high-level evidence from clinical studies.Based on research progress and clinical experience in China and other countries,the authors emphasize the necessity that facial flushing with erythema should be investigated as an independent clinical phenotype during the study.It is believed that mental stress,anxiety and/or depression may be driving factors in the pathogenesis of facial flushing with erythema.Based on mental factors,it is of potential clinical significance to investigate the relationship of neuroinflammation involved in facial flushing and erythema with skin immunity and blood vessels in rosacea.