C-Myc在多发性骨髓瘤中的研究进展

多发性骨髓瘤(multiple myeloma,MM)是一种浆细胞恶性增殖性疾病,其特点为克隆性浆细胞在骨髓中异常增殖,发病率在血液系统肿瘤中排第2位.C-Myc是一种原癌基因,在人类的多种实体肿瘤和血液肿瘤中异常高表达.近年来相关研究表明,C-Myc的表达增强与肿瘤的不良预后息息相关.从癌前病变单克隆丙种球蛋白病(m...

Research progress of C-Myc in multiple myeloma

Multiple myeloma(MM)is a plasma cell malignant proliferative disease characterized by the accumulation of clonal plasma cells in bone marrow.The incidence of multiple myeloma is second in hematological malignancies.C-Myc is an oncogene that high expresses abnormally in a variety of solid tumors and hematological malignancies.It has been approved that the increased expression of C-Myc is associated with poor prognosis of tumor patients.Multiple myeloma evolves from a premalignant stage named monoclonal gammopathy of undetermined significance(MGUS),followed by smoldering MM(SMM)and finally evolved to symptomatic myeloma.C-Myc deregulation is one of the key features of disease progression.Identifying the role of C-Myc in the occurrence and development of MM is important for clarifying the pathogenesis of MM and may help in developing new treatment strategies.