| 骨肉瘤组织中XIAP mRNA、Caspase-9 mRNA的表达变化及意义 |
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| 引用本文： | 何畔,梁珊.骨肉瘤组织中XIAP mRNA、Caspase-9 mRNA的表达变化及意义[J].山东医药,2010,50(14):13-15. |
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| 作者姓名： | 何畔 梁珊 |
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| 作者单位： | 湖南省人民医院,长沙,410005 |
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| 摘 要： | 目的观察X染色体连锁凋亡抑制蛋白（XiAP）mRNA和Caspase-9 mRNA在骨肉瘤中的表达变化及其与骨肉瘤临床病理指标的联系。方法采用原位杂交技术检测51例骨肉瘤组织中XIAP mRNA和Caspase-9 mRNA，并以10例骨软骨瘤（骨良性病变）组织为对照（对照组）。结果在51例骨肉瘤中XIAPmRNA和Caspase-9 mRNA的表达水平与骨肉瘤的临床病理特征无明显关系，XIAP mRNA的阳性表达率显著高于对照组（P〈0．05）；Caspase-9 mRNA则显著低于对照组（P〈0．05）；XIAP mRNA与Caspase-9 mRNA的表达呈等级负相关（r=-0．467，P〈0．05）。结论XIAP、Caspase-9 mRNA可能与骨肉瘤的发生、发展有关。以XIAP和Caspase-9为靶点进行诱导骨肉瘤细胞凋亡的治疗，将可能成为临床提高保肢手术成功率及患者生活质量的新治疗思路。
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| 关 键 词： | 骨肿瘤 X染色体连锁凋亡抑制蛋白 半胱氨酸蛋白酶-9 |
Expression and significance of XIAP mRNA and Caspase-9 mRNA in osteosarcoma |
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| HE Pan,LIANG Shan.Expression and significance of XIAP mRNA and Caspase-9 mRNA in osteosarcoma[J].Shandong Medical Journal,2010,50(14):13-15. |
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| Authors: | HE Pan LIANG Shan |
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| Institution: | HE Pan, LlANG Shan ( Hunan Provincial People＇s Hospital, Changsha 410005 ,P. R. China) |
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| Abstract: | Objective To investigate expression and significance of X-linked inhibit apoptosis protein(XIAP)mRNA and Caspase-9 mRNA in osteosarcoma.Method The XIAP mRNA and Caspase-9 mRNA of 51 osteosarcoma tissues and 10 osteochondroma tissues were detected by in situ hybridization method.Results The expression rate in osteosarcoma and osteochondroma had no obvious relationship with clinicopathology characteristics(P>0.05).The positive rate and grade of XIAP mRNA were significantly higher than that in the osteochondro... |
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| Keywords: | osteosarcoma X-linked inhibit apoptosis protein cysteine aspartic acic specific protease-9 |
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