| 盐酸氨基葡萄糖胶囊溶出度测定方法研究 |
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| 引用本文： | 张德柱,宋愿智,沈登林.盐酸氨基葡萄糖胶囊溶出度测定方法研究[J].西北药学杂志,2014(1):54-57. |
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| 作者姓名： | 张德柱 宋愿智 沈登林 |
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| 作者单位： | [1]陕西盘龙制药集团有限公司,柞水711400 [2]陕西省食品药品检验所,西安710065 |
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| 摘 要： | 目的建立紫外-可见分光光度法测定盐酸氨基葡萄糖胶囊溶出度的方法。方法按照《中国药典》2010年版二部附录溶出度测定法中第一法,以蒸馏水900mL为溶剂,转速100r·min-1,30min采样,依法在525nm波长处测定吸光度。结果盐酸氨基葡萄糖质量浓度在6.3231.60μg·mL-1范围内线性关系良好(r=0.999 9),平均回收率为100.6%,RSD为1.8%(n=9)。结论该方法简便、快速、准确,可用于盐酸氨基葡萄糖胶囊的质量控制。
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| 关 键 词： | 盐酸氨基葡萄糖 盐酸氨基葡萄糖胶囊 溶出度 紫外-可见分光光度法 |
Determination of dissolution for Giucosamine Hydrochloride Capsules |
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| ZHANG Dezhu,SONG Yuanzhi,SHEN Denglin.Determination of dissolution for Giucosamine Hydrochloride Capsules[J].Northwest Pharmaceutical Journal,2014(1):54-57. |
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| Authors: | ZHANG Dezhu SONG Yuanzhi SHEN Denglin |
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| Institution: | 1. Shaanxi Panlong Pharmaceutical Group Limited Company, Zhashui 711400;2. Shaanxi Institute for Food and Drug Control, Xi＇an 710065 ,China) |
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| Abstract: | Objective To establish an ultraviolet spectrometric method（UV）for the determination of dissolution of Glucosamine Hydrochloride Capsules.Methods ApparatusⅠdissolution test method of ChP 2010 edition Vol.Ⅱwas used.The dissolution me-dium was distilled water 900 mL,and the rotation speed was 100 r·min-1 .After 30 min the dissolution solution was taken and an-alyzed by UV at the wavelength of 525 nm.Results The linear relationship was in the range of 6.32-31.60 μg · mL-1 （r=0.999 9,n=9）,and the average recovery was 100.6%（RSD=1.8%）.Conclusion The method was convenient,rapid and ac-curate.It can be used for the quality control. |
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| Keywords: | glucosamine hydrochloride Glucosamine Hydrochloride Capsules dissolution ultraviolet spectrometry |
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