| 抗风湿中药制剂中非法添加多种化学成分的HPLC检测 |
| |
| 引用本文： | 刘 放,唐 靓.抗风湿中药制剂中非法添加多种化学成分的HPLC检测[J].西北药学杂志,2014(1):18-22. |
| |
| 作者姓名： | 刘 放 唐 靓 |
| |
| 作者单位： | [1]浙江省医学科学院药物研究所,杭州310013 [2]浙江省医学科学院保健食品研究所,杭州310013 |
| |
| 基金项目： | 浙江省公益性技术应用研究计划项目（编号：2012C037045） |
| |
| 摘 要： | 目的应用反相高效液相色谱-紫外检测(RP-HPLC-UV)技术分析检测抗风湿中药制剂中可能存在的化学药品成分。方法采用的色谱柱分别为Agilent HC C18(250mm×4.6mm,5!m);流动相为甲醇-1 mL·L-1醋酸水溶液(60∶40);流速:1mL·min-1;捡测波长240nm。结果 4种解热镇痛类化学药物和2种糖皮质激素化学药物,能在该色谱条件下得到分离和鉴定。结论该法简便、快速、准确,可用于中成药及保健品中非法添加解热镇痛类化学药物和糖皮质激素的检测。
|
| 关 键 词： | 高效液相色谱法 紫外检测器 醋酸泼尼松 醋酸地塞米松 萘普生 双氯芬酸钠 吲哚美辛 布洛芬 中药制剂 |
Determination of the illegal addictives in the traditional Chinese antirheumatic preparations by RP-HPLC-UV |
| |
| LIU Fang,TANG Liang.Determination of the illegal addictives in the traditional Chinese antirheumatic preparations by RP-HPLC-UV[J].Northwest Pharmaceutical Journal,2014(1):18-22. |
| |
| Authors: | LIU Fang TANG Liang |
| |
| Institution: | 1. Institute of Materia Medica of Zhejiang Academy of Medical Sciences, Hangzhou, 310013 ,China; 2. Institute of Health Food of Zhejiang Academy of Medical Sciences, Hangzhou,310013 ,China) |
| |
| Abstract: | Obj ective To determine the illegal addictives in the traditional Chinese antirheumatic preparations by reversed phase high performance liquid chromatography（RP-HPLC-UV）.Methods The separation was performed on an Agilent HC C18 column（250 mm×4.6 mm,5 mm）with detective wavelength at 240 nm.The mixture solution of methanol and 1 mL·L-1 acetic acid （60∶40） was used as the mobile phase with a flow rate of 1 .0 mL·min-1 .Results 4 kinds antipyretic analgesic chemical substances and 2 kinds glucocorticoid were proved to be separated completely under the selected chromatography conditions.Conclusion The meth-od is simple and accurate,and can be used for detecting antipyretic analgesic chemical substances and glucocorticoid aduherated in the preparations of traditional Chinese medicine and health food. |
| |
| Keywords: | HPLC UV prednisone acetate dexamethasone acetate naproxen： dielofenacsodium indomethacin ibuprofen traditio-nal Chinese medicines |
| 本文献已被 CNKI 维普 等数据库收录！ |
