致病性真菌146株检出及耐药情况分析

目的探讨致病性真菌的种类及其耐药性.方法用API-20CAUX鉴定系统进行真菌的分离和鉴定,用ATB真菌药敏试验条进行药敏试验.结果506例受检标本分离出致病性真菌146株,阳性率为29.41%.白色念株菌分离率最高,为45.89%.药敏试验显示：146株致病真菌对5-氟胞嘧啶（5-FC）、二性霉素B（AMB）、制霉菌素（NYS）、咪康唑（MIC）、益康唑（ECO）、酮康唑（KET）的敏感率分别为93.8%、91.7%、89.7%、83.6%、82.2%和75.3%.结论致病性真菌的耐药性监测,对指导临床治疗具有重要意义.

Drug resistance and distribution of 146 strains of pathogenic fungi

Objective To investigate the type of clinical pathogenic fungus and their drug resistance.Methods The pathogenic fungus isolated from clinical specimens had been identfied by API-20CAUX system and sensitive test of medicine had been performed by ATB fungistat test strip method.Results From 506 tested specimens,146 strains pathogenic fungus were segregated;The posititve rate was 29.41%.Candida albicans was the major pathogenic pathogens in this study.The percentage of culture was 45.89%.The results of susceptibility test showed:for 146 pathogenic fungus,the seneitivity to 5-Flurocytosine,amphotericin B,nystatin,miconazole,econazole,ketoconazole was 93.8%,91.7%,89.7%,83.6%,82.2% and 75.3% respectively.Conclusion Drug resistance monitoring of pathogenic fungus has important significance in clinical drug treatment.