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Clinical significance of IgG subclasses of anti-Sm and U1 ribonucleoprotein antibodies in patients with systemic lupus erythematosus and mixed connective tissue disease |
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| Authors: | Yoshiaki Tokano Mitsuhiko Yasuma Shigenori Harada Yoshinari Takasaki Hiroshi Hashimoto Ko Okumura Shunichi Hirose |
| Institution: | (1) Division of Rheumatology, Department of Internal Medicine, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113 Tokyo, Japan;(2) Shionogi Institute for Medical Science, Shionogi and Co. Ltd., 2-5-1 Mishima, Settsu-shi, 566 Osaka, Japan;(3) Department of Immunology, Juntendo University, School of Medicine, Bunkyo-ku, 113 Tokyo, Japan |
| Abstract: | IgG subclasses of anti-Sm and anti-U1 ribonucleoprotein (U1 RNP) antibodies were determined using a new clone of the anti-IgG2 antibody (HG2-56F). Although the predominance of IgG1 coincided with previous reports, IgG2 anti-Sm and U1 RNP antibodies were detected in numerous patients. IgG3 anti-Sm antibody significantly correlates with joint involvement and a high titer of anti-DNA antibody. On the other hand, IgG4 anti-U1 RNP antibody significantly correlated with esophageal dilation and muscular involvement. These results may suggest that some IgG subclasses are related to a specific clinical feature or manifestation. |
| Keywords: | IgG subclass anti-Sm antibody anti-U1 ribonucleoprotein antibody systemic lupus erythematosus (SLE) mixed connective tissue disease (MCTD) |
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