The antigen-major histocompatibility complex-T cell receptor interaction |
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Authors: | William V. Williams David B. Weiner Scott Wadsworth Mark I. Greene |
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Affiliation: | Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia. |
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Abstract: | In summary, we wish to propose that regions on MHC molecules interact with complementary regions on processed peptide antigens, and that the resultant Ag-MHC complex forms a conformation with separate functional regions that are able to interact with similarly complementary areas on T cell receptors. It is the product of these interactions that determines whether a given peptide Ag is capable of binding the MHC molecule, and whether a given Ag-MHC complex is capable of stimulating a particular T cell. As more becomes known about the molecular aspects of MHC-restricted, Ag-specific T cell activation, it will become clear which amino acid residues on the Ag, MHC, and TCR are involved in these interactions. |
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