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A novel sequence in kangaroo angiotensin I |
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| Authors: | J B Best J R Blair-West J P Coghlan E J Cran R T Fernley P A Simpson |
| Institution: | Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne;Department of Medicine, Monash University, Melbourne, Victoria, Australia |
| Abstract: | SUMMARY 1. The incubation of kangaroo renin-substrate with renin from kangaroo, hog or sheep yields angiotensin having pressor activity in the rat. 2. Kangaroo angiotensin I is not reactive in radioimmunoassay which is sensitive to other forms of angiotensin I. 3. Kangaroo angiotensin I is converted by passage through the rat pulmonary circulation or by equine converting enzyme to a reactive product in radioimmunoassay for angiotensin II. 4. The findings suggest that the amino acid sequence of kangaroo angiotensin I differs from that of other known angiotensins. |
| Keywords: | angiotensin I angiotensin II kangaroo |