Cushing's Syndrome Secondary to Olfactory Neuroblastoma |
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| Authors: | Mark A. Arnesen Bernd W. Scheithauer Susan Freeman |
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| Affiliation: | a Department of Pathology, Abbott Northwestern Hospital, Minneapolis, Minnesota, USAb Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USAc Abbott Northwestern Hospital, Minneapolis, Minnesota, USA |
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| Abstract: | A case of olfactory neuroblastoma in a 36-year-old woman who presented with florid Cushing's syndrome is reported. A nasal polyp, which proved to be an olfactory neuroblastoma, was resected. The procedure was followed by complete remission from the endocrinologic abnormalities. Postoperatively, the patient was well for 5 years until recurrence of both Cushing's syndrome and the nasal polyp was noted. Following combined transnasal-transcranial resection of the tumor, which extended into the anterior cranial fossa, the patient again experienced complete remission of Cushing's syndrome. Immunohistochemistry showed the tumor to be positive for neuron-specific enolase, synaptophysin, chromogran-in, adrenocorticotropic hormone, (J-endorphin, and S-100 protein. Electron microscopy revealed neuritic processes containing microtubules and neurosecretory granules. This is the first reported case of Cushing's syndrome secondary to olfactory neuroblastoma. |
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| Keywords: | Cushing's syndrome electron microscopy immunohistochemistry neuroendocrine carcinoma primitive neuroectodermal tumor olfactory neuroblastoma |
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