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| 银杏石榴煎治疗银屑病疗效观察及患者血清中肿瘤坏死因子-α、白介素-6及白介素-8表达水平的变化 | |
| 引用本文： | 羌建峰,曹双林,陈威,姚登福,傅琳玲,符梅.银杏石榴煎治疗银屑病疗效观察及患者血清中肿瘤坏死因子-α、白介素-6及白介素-8表达水平的变化[J].中国中西医结合皮肤性病学杂志,2008,7(4). |
| 作者姓名： | 羌建峰 曹双林 陈威 姚登福 傅琳玲 符梅 |
| 作者单位： | 1. 南通大学医学院,南通,226001 2. 南通大学附属医院,南通,226001 3. 江苏启东市中医院,启东,226100 |
| 摘 要： | 目的采用中药银杏石榴煎治疗进行期寻常性银屑病，观察该煎剂对银屑病疗效并检测治疗前后患者血清中肿瘤坏死因子（TNF）-α、白介素（IL）-6及IL-8表达水平变化。方法银杏石榴煎治疗前后对银屑病患者皮损进行PASI评分，采用ELISA法检测银屑病患者治疗前后和正常对照者血清中TNF—α、IL-6及IL-8的表达水平变化。结果①银杏石榴煎可显著改善银屑病患者临床症状，治疗前后PASI评分明显下降（P〈0．01）。②患者血清中TNF-α、IL-6及IL-8水平明显高于正常对照（P〈0．01），治疗后其表达水平较治疗前明显下降（P〈0．05）。③患者体内TNF-α及IL-8表达水平与PASI积分呈正相关（P〈0．05）。结论银杏石榴煎为治疗银屑病的有效药物；患者血清TNF—α、IL-6、IL-8表达水平与银屑病患者的病情变化密切相关。 |
| 关 键 词： | 银屑病 银杏 石榴 TNF-α IL-6 IL-8 |
Observation of Chinese Medicine Gingkgo and Megranate Treatment and Its Affection on Tumor Necrosis Factor-a, Interleukin-6 and Interleukin-8 in Patients with Psoriasis |
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| QIANG Jian-feng,CAO Shuang-lin,CHEN Wei,YAO Deng-fu,FU Lin-ling,FU Mei.Observation of Chinese Medicine Gingkgo and Megranate Treatment and Its Affection on Tumor Necrosis Factor-a, Interleukin-6 and Interleukin-8 in Patients with Psoriasis[J].Chinese J of Dermatovenerology Integr Tradit and West Med,2008,7(4). | |
| Authors: | QIANG Jian-feng CAO Shuang-lin CHEN Wei YAO Deng-fu FU Lin-ling FU Mei |
| Institution: | QIANG Jian-feng1,CAO Shuang-lin2,CHEN Wei3,YAO Deng-fu2,FU Lin-ling2,FU Mei2 1.Nantong Medical University,Nantong 226001,China,2. Affiliated Hospital of Nantong Medical University,Nantong 226001,China,3. Qidong Hospital of Traditional Chinese Medicine,Nantong 226100,China |
| Abstract: | |
| Keywords: | IL-6 IL-8 |
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