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An anti-CD3? serum detects T lymphocytes in paraffin-embedded pathological tissues in many animal species |
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| Authors: | G. Keresztes ,R. Glá vits,L. Krená cs,É . Kurucz,I. Andó |
| Affiliation: | a Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary b Central Veterinary Institute, Budapest, Hungary c Department of Pathology, Albert Szent-Györgyi Medical University, Szeged, Hungary |
| Abstract: | The in situ identification of T cells has been difficult and restricted to frozen tissue samples of a limited range of species. In this study, we demonstrate that an antiserum recognizing a phylogenetically conserved part of the CD3ε cytoplasmic tail detects T cells of many avian and mammalian species in formalin-fixed paraffin-embedded tissue sections. This antiserum enables the morphological characterization of normal and pathological lymphoid tissues and lymphoid infiltrations in experimental work and in animal disease. |
| Keywords: | Immunohistochemistry T cells Avian and mammalian CD3ε Formaldehyde fixation |
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