Hyperhomocysteinaemia; with reference to its neuroradiological aspects |
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| Authors: | M. van den Berg M. S. van der Knaap G. H. J. Boers C. D. A. Stehouwer J. A. Rauwerda J. Valk |
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| Affiliation: | (1) Department of Surgery, Division of Vascular Surgery, Free University Hospital, P.O. Box 7057, NL-1007 MB Amsterdam, The Netherlands;(2) Department of Child Neurology, Free University Hospital, Amsterdam, The Netherlands;(3) Department of Internal Medicine, Division of Endocrinology, University Hospital, Nijmegen, The Netherlands;(4) Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands;(5) Department of Radiology, Free University Hospital, Amsterdam, The Netherlands |
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| Abstract: | Severe or even mild hyperhomocysteinaemia can cause a wide range of neurological problems. In recent years its vascular complications, including cerebral stroke, in children and young adults have gained special interest, because hyperhomocysteinaemia is treatable and recurrence of vascular incidents may be preventable. Current knowledge about biochemical mechanisms leading to hyperhomocysteinaemia, the pathogenesis of vascular pathology and neurological disfunction, and the various patterns of cerebral damage are reviewed. The significance of MRI in diagnosis, follow-up and research on hyperhomocysteinaemia is discussed. |
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| Keywords: | Hyperhomocysteinaemia Premature arteriosclerosis Demyelination Magnetic resonance imaging |
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