抗抑郁治疗对腹泻型肠易激综合征患者肠道敏感性的影响

目的 观察腹泻型肠易激综合征(IBS-D)伴抑郁状态患者抗抑郁治疗前后症状积分、汉密尔顿抑郁量表(HAMD)积分及直肠敏感性的变化,评价抗抑郁药物在IBS-D治疗中的作用.方法 依据RomeⅢ标准和CCMD3标准将符合IBS-D伴抑郁状态的患者随机分为研究组和对照组,前者给予常规治疗加抗抑郁药物及心理疏导,后者给予常规药及对症治疗.治疗前后分别进行症状积分、HAMD积分及直肠敏感性测定,并进行统计学分析.结果 研究组与对照组治疗后及研究组治疗前后症状积分、HAMD积分、直肠敏感性比较差异均有统计学意义(P<均0.01).结论 伴抑郁状态的IBS-D患者加用抗抑郁药物能减轻临床症状,降低肠道敏感性,从而改善与之相关的疼痛,其疗效优于对照组.Abstract：Objective To evaluate the effect of antidepressant treatment for the diarrhea-predominant irritable bowel syndrome(IBS-D),by observing the changes of clinical symptom score,HAMD scale score and the regulation of intestinal sensations in IBS-D with depress patients before and after treatment. Methods Accord to ROMEⅢ standard and CCMD3 standard,all IBS-D with depress patients were randomly divided into two groups. The study group was given antidepressant treatment plus conventional treatment and mental adjustment treatment, and the control group was given conventional treatment.All the cases received symptom score,HAMD scale score evaluating and evaluating the regulation of intestinal sensations before and after antidepressant treatment. Results The study group comparing with the control group after treatment and the study group itself before treatment comparing with after treatment, was significantly different in symptoms score, HAMD score, and the regulation of visceral sensations (all P<0.01). Conclusions For the patients of IBS with depress using antidepressant drug can significantly alleviate the physical symptoms, and antidepressant treatment can improvethe threshold of visceral sensation and alleviate the physical symptom such as pain.

Effect of antidepressant treatment on regulation of intestinal sensations in the diarrhea-predominant irritable bowel syndrome

Irritable bowel syndrome Antidepressant treatment Visceral sensation Rectal-distention