β-Cyclodextrin: a green supramolecular catalyst assisted eco-friendly one-pot three-component synthesis of biologically active substituted pyrrolidine-2-one |
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| Authors: | Subhankar Paul Sharmistha Das Bijeta Mitra Gyan Chandra Pariyar Pranab Ghosh |
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| Affiliation: | a Department of Chemistry, University of North Bengal, District-Darjeeling, West Bengal India, Fax: +91 0353 2699001, +91 0353 2776381 ; b Department of Food Technology, University of North Bengal, District-Darjeeling, West Bengal India |
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| Abstract: | A green, novel and eco-efficient synthetic route towards the synthesis of highly substituted bio-active pyrrolidine-2-one derivatives was demonstrated using β-cyclodextrin, a water-soluble supramolecular solid as a green and eco-benign catalyst at room temperature under water–ethanol solvent medium. The exploration of the green catalyst β-cyclodextrin for the metal-free one-pot three-component synthesis of a wide range of highly functionalized bio-active heterocyclic pyrrolidine-2-one moieties from easily available aldehydes and amines explains the superiority and uniqueness of this protocol. An eco-efficient protocol towards the synthesis of highly substituted bio-active pyrrolidine-2-one derivatives was demonstrated using β-cyclodextrin, a water-soluble supramolecular catalyst at room temperature under water–ethanol solvent medium. |
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