Enhanced humoral immune response in rats by hyaluronic acid |
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| Affiliation: | 1. Oral Surgery Department, Regional Hospital Halmstad, Halmstad, Sweden;2. Oral and Maxillofacial Radiology Department, Regional Hospital Halmstad;1. Department of Orthopedics, Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, China;2. Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Linggong Road, Dalian, China;3. Postdoctoral Workstation, Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, China;4. First Hospital and Institute of Immunology, Jilin University, Changchun, Jilin, China |
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| Abstract: | The effect of hyaluronic acid (HA) on antibody responses to egg albumin, dog albumin and birch pollen proteins, was studied in rats. The highest antibody responses to dog and egg albumin were obtained in rats immunized with a coprecipitate of the antigen with HA. However, pretreatment of rats with a subcutaneous injection of HA up to three (3) days prior to the priming injection of dog albumin also significantly enhanced the secondary antibody responses to that antigen. Possible explanations of this stimulatory effect on the humoral immune response are discussed. |
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