Duration of complete response to chemotherapy in advanced breast cancer |
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| Affiliation: | 1. Basel Academy for Quality and Research in Medicine, Steinenring 6, CH-4031Basel, Switzerland;2. Department of Environmental Sciences, University of Basel, Spalenring 145, CH-4055 Basel, Switzerland;3. Department of Nuclear Medicine, Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark;4. Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, DK-5000 Odense C, Denmark;1. Azafaros AG, Dufourstrasse 25, 4052 Basel, Switzerland;2. Principal Investigator, CMAX Research Phase 1 Unit, Ground Floor 21-24 North Terrace, Adelaide, 5000, SA, Australia;3. Department of Clinical Pharmacology, Royal Adelaide Hospital, Port Rd, Adelaide, SA 5000, Australia |
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| Abstract: | Twenty-seven patients with advanced breast cancer with complete response (CR) to chemotherapy have been analysed and observed for up to 8 years. Median time to attainment of CR was 8.1 months (range, 1–19.5) and median duration of CR was 27.5 months (1–97 + months). Most (16) recurrences occurred in the first 2 years. In 12 patients (63%) relapse was at sites initially involved. No clear relationship between the duration of CR and a variety of prognostic factors or the dose of cytotoxic drugs given was found, although there was a tendency to longer duration of CR when fewer sites were involved. The presence of visceral disease did not preclude a prolonged CR. It seems that despite some patients surviving many years, relapse is inevitable and cure of the disease is unlikely with presently available chemotherapy. |
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