Behavioural effects of hashish in mice in comparison with other psychoactive drugs |
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| Affiliation: | 1. Mood and Anxiety Disorders Research Program, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States;2. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States;3. Mental Health Service, Jesse Brown VA Medical Center, Chicago, IL, United States;4. Department of Psychology, University of Illinois at Chicago, United States;5. Stanford University, Department of Psychology, Stanford, CA, United States;1. Department of Biological Sciences, 1812 Sir Isaac Brock Way, Brock University, St. Catharines, ON L2S 3A1, Canada;2. Centre for Neuroscience, 1812 Sir Isaac Brock Way, Brock University, St. Catharines, ON L2S 3A1, Canada;4. eCB Consulting Inc., PO Box 652, 3 Cameron St. W., Cannington, ON L0E 1E0, Canada;5. Medical Cannabis Canada, 601-3500 Lakeshore Rd. W., Oakville, ON L6L 0B4, Canada;6. Department of Psychology, 1812 Sir Isaac Brock Way, Brock University, St. Catharines, ON L2S 3A1, Canada |
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| Abstract: | - 1.1. The behavioural effects of hashish extract (10 mgΔ9-THC/kg) were compared to those of morphine (20 mg/kg), diazepam (10 mg/kg), imipramine (10 mg/kg), amphetamine (10 mg/kg) and chlorpromazine (10 mg/kg) by testing male mice in a resident-intruder situation.
- 2.2. The drugs were given either to the resident or to the intruder male.
- 3.3. Hashish extract similar to diazepam and chlorpromazine reduced social activities in resident and intruder males.
- 4.4. Intruder males treated with hashish or diazepam were more frequently attacked and submission and flight was increased.
- 5.5. Amphetamine and morphine stimulated locomotion and non-social activities but impaired social behaviour especially in residents.
- 6.6. Imipramine increased aggressive behaviour in resident and intruder males.
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