The effect of oral contraceptives on reproductive function during semichronic exposure to ethanol by the female rat |
| |
| Affiliation: | 1. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA;2. Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA;3. Department of Psychology, University of Kentucky, Lexington, KY, USA;4. Department of Family and Community Medicine, University of Kentucky, Lexington, KY, USA;5. Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA |
| |
| Abstract: | - 1.1. Female rats were placed on water, 5% ethanol (ET), or 20% ET drinking solutions for 8 weeks. The last 2 weeks, the rats received orally either ethinyl estradiol (EE), norethindrone acetete (NED), or a combination of both.
- 2.2. Luteinizing hormone decreased due to ET drinking and was undetectable subsequent to the steroidal treatment.
- 3.3. Prolactin increased after steroid treatment and alcohol drinking in the controls.
- 4.4. Ethanol (5%) plus EE increased prolactin as did the steroidal combination, whereas ET (20%) likewise increased prolactin in conjunction with NED over water controls.
- 5.5. Hepatic alcohol dehydrogenase was inhibited due to EE when compared to water-controls in the 5% ET drinking animal, whereas aldehyde dehydrogenase was induced in combination with NED in both the 5% and 20% ET drinking rats.
|
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
