血管内皮生长因子受体与肝细胞癌血管生成关系的研究进展

新生血管是肿瘤生长和转移的基础.肝细胞肝癌是典型的多血管肿瘤,其发生、发展、转移、侵袭都和血管生成密切相关.血管的生成主要依靠血管生长因子和血管生长抑制因子的调控,其中研究最多也是最重要的是血管内皮生长因子(VEGF)及其受体(VEGFR).VEGFR在机体内作用不同,参与肝癌血管生长的主要是VEGFR-1(flt-1)和VEGFR-2(flk-1).针对VEGFR的抗肿瘤血管治疗在实验室取得了不错的疗效,部分已经进入了临床试验.

Advancement of the relationship between vascular endothelial growth factor receptors and angiogenesis of hepatocellular carcinoma

Angiogenesis is the basis of tumor growth and metastasis.Hepatocellular carcinoma is a kind of typical multivessel tumor,whose generation, progression and invasion are closely related with the angiogenesis.The angiogenesis is mainly regulated by angiogenins and anti-an- giogenins,of which vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are the most important.Different kinds of VEGFR have various functions in vivo,and VEGFR-1 (flt-1) and VEGFR-2 (flk-1) are involved in the angio- genesis HCC.Satisfactory effects have been ob- tained by the anti-angiogenic therapies targeting on VEGFR in laboratory studies,some of which have been launched in clinical experiments.