One-Minute Dynamic Cerebral Autoregulation in Severe Head Injury Patients and its Comparison with Static Autoregulation. A Transcranial Doppler Study |
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Authors: | Corina Puppo Lucía López Elia Caragna Alberto Biestro |
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Institution: | (1) Intensive Care Unit, Hospital de Clínicas, Universidad de la República, Avenida Italia s/n, CP 11200, Montevideo, Uruguay;(2) Unidad Neurocrítica, IMPASA, Montevideo, Uruguay |
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Abstract: | Objective To compare dynamic and static responses of cerebral blood flow to sudden or slow changes in arterial pressure in severe traumatic
brain injury (TBI) patients.
Design Prospective study.
Patients and Methods We studied 12 severe TBI patients, age 16–63 years, and median GCS 6. We determined the dynamic cerebral autoregulation: response
of cerebral blood flow velocity to a step blood pressure drop, and the static cerebral autoregulation: change in cerebral
blood flow velocity after a slow hypertensive challenge.
Results During the dynamic response, the median drop in arterial pressure was 21 mm Hg. Dynamic response was graded between 9 (best)
and 0 (worst). The median value was 5; four patients showed high values, (8–9), five patients showed intermediate values (4–6).
In three patients (value = 0), the CBFV drop was greater than the cerebral perfusion pressure drop, and maintained through
60 s. The static cerebral autoregulation was preserved in 6/11 patients. The comparison between the two showed four different
combinations. The five patients with impaired static cerebral autoregulation showed unfavorable outcome.
Conclusions A sharp dynamic vasodilator response could not be sustained, and a slow or absent reaction to a sudden hypotensive challenge
could show an acceptable cerebral autoregulation in the steady state. We found that patients with impaired static cerebral
autoregulation had a poor outcome, whereas those with preserved static cerebral autoregulation experience favorable outcomes. |
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Keywords: | Severe head injury Cerebral autoregulation Outcome Cerebral perfusion pressure Intracranial pressure |
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