癌胚抗原神经元特异性烯醇酶CYFRA21-1联合检测在肺癌诊断中的应用

目的通过与CT、支气管镜诊断结果的比较,评价CYFRA21-1、神经元特异性烯醇酶(NSE)、癌胚抗原(CEA)联合检测在肺癌诊断中的临床价值。方法对268例明确诊断肺癌患者的CT、支气管镜、CY-FRA21-1、NSE、CEA联合检测结果进行了分析。结果CT、支气管镜、CYFRA21-1、NSE、CEA联合检测三种方法诊断肺癌的灵敏度分别为95.2%、77.6%、90.0%。三种方法联合可以诊断全部肺癌患者。支气管镜诊断中央型肺癌的灵敏度为92.9%,但对于周围型肺癌仅19.6%;CYFRA21-1、NSE、CEA联合检测在周围型和中央型肺癌两组患者中差异无统计学意义。结论①在周围型肺部占位患者中进行CYFRA21-1、NSE、CEA联合检测是必要的;②CT、支气管镜、CYFRA21-1、NSE、CEA联合检测三种方法联合诊断将提高肺癌诊断的灵敏度。

Combined determination of CEA, NSE and CYFRA-21-1 to diagnose lung cancer

Objective To evaluate the diagnostic value of the combined determination of CYFRA21-1,NSE and CEA in lung cancer compared with CT and bronchoscopy examination.Methods All 268 patients with lung cancer were examined by CT,bronchoscopy and combined determination of CYFRA21-1,NSE and CEA.Results The sensitivity of CT,branch endoscope and combined determination of CYFRA21-1,NSE and CEA for lung cancer was 95.2%,77.6% and 90.0%,respectively.All the patients could be diagonosed by combined determination of the 3 methods.The sensitivity of bronchoscopy in central lung cancer was 92.9%,but in perpeal lung cancer 19.6%.There was no significent difference between central lung cancer and perperal lung cancer using the combined determination of CYFRA21-1,NSE and CEA.Conclusion ①The combined determination of CYFRA21-1,NSE and CEA is necessary for peripheral lung cancer;②The combined diagnosis with the 3 methods will improve the sensitivity for lung cancer.