Outcome of patients with early stage lung cancer |
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Authors: | Hiroyuki Miura Haruhiko Nakamura Osamu Taira Osamu Uchida Harubumi Kato Chimori Konaka |
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Institution: | (1) Department of Thoracic Surgery, Hachioji Medical Center of Tokyo Medical College Hospital, 1163 Tate-machi, 193 Hachioji, Tokyo, Japan;(2) Department of Surgery, Tokyo Medical College Hospital, 6-7-1 Nishi-shinjuku, Shinjuku-ku, 160 Tokyo, Japan |
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Abstract: | A study was conducted to evaluate the outcomes of 79 patients with early stage lung cancer diagnosed according to the following
criteria. Central tumors were located in the segmental bronchi, or more proximally, and tumor invasion was limited to the
bronchial wall without lymph node or distant metastases. Peripheral tumors were located distal to the subsegmental bronchi
and were less than 2 cm in greatest dimension, and invasion was limited to the visceral pleura, with no lymph node or distant
metastases. The 5-year survival rate was 100% for patients with peripheral type early squamous cell carcinoma, 94.6% for those
with central-type early squamous cell carcinoma, and 79.3% for those with early adenocarcinoma. The 5-year survival rate for
patients with central-type squamous cell carcinoma without pericartilage layer invasion was 97.0%, and that for those with
T1N0M0 peripheral squamous cell carcinoma was 100.0%. To define early stage lung cancer as curable, it should be defined as
T1N0M0, peripheral squamous cell carcinoma, or central squamous cell carcinoma without pericartilage layer invasion. For other
histologic types, some added parameters are needed. The rate of multiple lung cancers was 10.1% and that of multiple primary
malignant disease was 13.9%. Thus, careful followup of patients with early stage lung cancer should be carried out, as second
malignancies in the lung and elsewhere are commonly detected. |
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Keywords: | lung cancer early stage lung cancer criteria outcome |
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