The Availability for Recognition of Normal H-2 Antigens by Cytotoxic T Lymphocytes on a Rauscher-Virus-transformed Cell, RBL-5A |
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| Authors: | A. WATSON D. A. ZARLING F. H. BACH |
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| Affiliation: | Immunobiology Research Center and Departments of Pathology, Medical Genetics and Surgery, University of Wisconsin, Madison, Wisconsin, USA |
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| Abstract: | The availability for recognition of cell surface H-2Db antigenic determinants on RBL-5A cells in comparison to normal C57BL/L cells was investigated by an in vitro immunological assay. No differences in the immunological recognition of the H-2Db antigens on RBL-5A cells compared to normal C57BL/L cells were detected. This assay system, however, readily detected changes in the H-2Kb determinant profile on target cells from the C57BL/L H-2Kb region mutant strains H(zl) and H(zl70) when compared to normal C57BL/6 mice. The result obtained with RBL-5A target cells therefore suggests that Rauscher murine leukaemia virus transformation does not induce, either genotypically or phenotypically, an immunologically recognizable alteration of the H-2Db antigen profile on this cell. |
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