浙江省温州市瓯海区健康人群脊髓灰质炎抗体水平监测分析

目的 了解浙江省温州市瓯海区实施脊髓灰质炎疫苗(OPV)常规及强化免疫后常住和流动人群中脊髓灰质炎病毒的抗体水平,评价免疫效果,为制定免疫策略提供依据.方法 采取分层整群随机抽样法,在2个调查点的常住和流动人群中随机调查1岁、1-2岁、3-4岁、5-6岁、7-14岁、15-19岁、20岁7个年龄组各15～20人,共478人.采集血液样品,以细胞中和试验法检测中和抗体.结果 常住人群中的脊髓灰质炎Ⅰ型、Ⅱ型、Ⅲ型病毒中和抗体的阳性率分别为97.53%、98.77%、93.83%,抗体几何平均滴度(GMT)分别为1:104.53、1:131.33、1:37.87;流动人群中的中和抗体的阳性率分别为96.60%、95.74%、88.51%,GMT分别为1:120.31、1:1 10.12、1:31.25.结论 温州市瓯海区通过OPV常规免疫和强化免疫后,已形成对脊髓灰质炎病毒有效的免疫屏障.但流动人群免疫水平低于常住人群,因此加强流动儿童的免疫规划管理将有助于提高脊髓灰质炎的预防效果.

Surveillance analysis of polio antibody levels in healthy population in Ouhai district,Wenzhou city,Zhejiang province

Objective The study was conducted to investigate the poliovirus antibody levels among local residents and floating population after the routine and intensified immunization with oral polio vaccine （OPV） in Ouhai district, Wenzhou city, Zhejiang province, and evaluate the immunization effects, providing evidence for the formulation of immunization strategies in future. Methods Seven age groups （〈1 years, 1 to 2 years, 3 to 4 years, 5 to 6 years, 7 to 14 years, 15 to 19 years, and ≥20 years） with 15 to 20 persons in each selected from local residents and floating population using the stratified random sampling method were surveyed, resulting in a total of 478 participants. Blood samples were collected and tested for the neutralizing antibodies using the neutralization test. Results The neutralizing antibody-positive rates for poliovirus type I , Ⅱ, Ⅲ were 97.53%, 98.77% and 93.83% respectively among local residents, the geometric mean titers （GMT） being 1：104.53,1：131.33, and 1：37.87. The neutralizing antibody positive rates among floating population were 96.60%, 95.74%, 88.51%, respectively, the GMT being 1：120.31, 1：110.12, and 1：31.25. Conclusion An effective immune barrier has been established after the implementation of routine and intensified OPV immunization in Ouhai district, Wenzhou city. However, the immunity levels of floating population were lower than the immunity levels of local residents. Therefore, the improvement of the immune planning and management for floating children will contribute to the prevention of polio.