去氧萍蓬碱的镇痛抗炎作用

从萍蓬草中提取的去氧萍蓬碱20mg/kg ip能显著提高小鼠热板法及电刺激法的痛阈,15～20mg/kg ip能显著降低醋酸所致扭体反应发生率。它亦能抑制醋酸所致的腹腔炎性渗出,且有明显的量—效关系。还能降低鸡蛋清所致踝关节肿胀程度,其强度与地塞米松4～8mg/kg相似。

ANALGESIC AND ANTIINFLAMMATORY EFFECTS OF DEOXYNUPHARIDINE

Deoxynupharidine is one of the alkaloids extracted trom Nuphar pumilum ( Timm ) DC which has been used in the treatment of arthritis and lumber-leg pain in folk medicine. This article presents the results of the experimental study of the analgesic and antiinflamma-tory actions of deoxynupharidine. Deoxynupharidine, ip, 15-20mg/kg, increased significantly the pain threshold of thermal and electrical stimulation in mice, and decreased significantly the rate and frequency of the development of body twisting reaction induced by ip acetic acid. Deoxynupharidine also significantly reduced exudation of acetic acid-induced inflammation in peritoneal cavity of mice. Data also showed that deoxynupharidine 15-20mg/kg and dexamethasone 4-8mg/kg produced a similar inhibing effeet on the degree of ankle swelling induced by subcutaneous injection of egg albumin. Dose-response relationship was seen in the above experiment. These resalts provide evidences for the clinial appli cation of deoxyuupharidine in the treatments of arthrtis and other inflammatory diseases.