| 中枢神经系统的免疫学特性与神经干细胞移植的免疫排斥问题 |
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| 引用本文： | 胡苏华,武衡,刘爱群.中枢神经系统的免疫学特性与神经干细胞移植的免疫排斥问题[J].国际脑血管病杂志,2006,14(7):547-551. |
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| 作者姓名： | 胡苏华 武衡 刘爱群 |
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| 作者单位： | 421001,衡阳,南华大学附属第一医院神经内科;421001,衡阳,南华大学附属第一医院神经内科;421001,衡阳,南华大学附属第一医院神经内科 |
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| 摘 要： | 中枢神经系统被认为是免疫特免器官,但其免疫特免性并不完全,组织移植后也可发生免疫排斥反应。神经干细胞(NSC)移植为治疗多种中枢神经系统疾病开辟了崭新的途径。尽管NSC具有低免疫原性,但也存在免疫排斥反应的困扰。文章就中枢神经系统的免疫学特征、中枢神经系统内免疫应答及免疫排斥反应的机制和NSC移植的免疫排斥问题进行了综述。
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| 关 键 词： | 中枢神经系统 神经干细胞 免疫排斥 |
| 收稿时间： | 2006-03-17 |
| 修稿时间： | 2006年3月17日 |
The Immunological Characteristics of Central Nervous System and the Problems of Immunological Rejection of Neural Stem Cell Transplantation |
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| Su-Hua Hu,Heng Wu,Ai-Qun Liu.The Immunological Characteristics of Central Nervous System and the Problems of Immunological Rejection of Neural Stem Cell Transplantation[J].International Journal of Cerebrovascular Diseases,2006,14(7):547-551. |
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| Authors: | Su-Hua Hu Heng Wu Ai-Qun Liu |
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| Institution: | Department of Neurology, the First Affiliated Hospital of Nanhua University, Hengyang 421001, China |
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| Abstract: | It is considered that the central nervous system (CNS) is an immunologically privileged organ, but its immunological privilege is not complete, and immunological rejection may also occurred after tissue transplantation. Neural stem cell (NSC) transplantation has developed a brand-new approach for the treatment of various CNS diseases. Despite the low immunogenicity of NSC, there are also troubles of immunological rejection. This article reviews the immunological characteristics of CNS, the mechanisms of immunological response and immunological rejection in CNS, as well as the problems of immunological rejection of NSC transplantation. |
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| Keywords: | central nervous system neural stem cell immunological rejection |
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