女大学生乳腺纤维腺瘤患者的血清激素水平研究

目的　探讨青年女性乳腺纤维腺瘤的内分泌病因 ,为研究乳腺纤维腺瘤的发病机理提供参考依据。方法　采用LLJ 1冷光乳腺检查仪对 5 4 8名女大学生进行乳房发育状况检查 ;采用放射免疫分析方法 (RIA)检测 2 4例女大学生乳腺纤维腺瘤患者和 16例正常女大学生的 5种血清激素水平。结果　在 5 4 8名女大学生中发现 2 4例乳腺纤维腺瘤患者 ,占总人数的 4 .4 % ;患者的血清Cor和Pg水平高于对照 ,前者有显著性差异 (P <0 .0 5 ) ,后者有极显著性差异 (P <0 .0 1) ;患者的血清T和E3 水平低于对照 ,前者有极显著性差异 (P <0 .0 1) ,后者有显著性差异 (P <0 .0 5 ) ;患者的血清Ins水平与对照无显著性差异 (P >0 .0 5 )。结论　性激素紊乱及部分非性激素的异常可能是青年女性乳腺纤维腺瘤的发病因素之一。

Study of serum hormone levels in female college students with breast fibroadenoma

Objective To probe into the endocrine pathogeny of breast fibroadenoma in young women and to provide reference for studying its mechanism. Methods RIA method was used to determine 5 kinds of serum hormone (Cor, T, Ins, Pg, E 3 ) levels in female college students with breast fibroadenoma and in controls. Results The percentage of patients with breast fibroadenoma in 548 female college students was 4.4%. The serum Cor and Pg levels in patients were higher than those in controls, the former had significant difference ( P <0.05), while the latter had markedly significant difference ( P <0.01). The serum T and E 3 levels in patients were lower than those in controls, the former had markedly significant difference ( P <0.01), while the latter differed significantly ( P <0.05). Conclusion The abnormality of sex hormone levels (T, Pg, E 3 ) and some of the non sex hormones may be one of the important pathogeny for the occurrence of breast fibroadenoma in young women.