Immediate and remote effects of antitumor drug on the morphology of rat liver |
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| Authors: | E. D. Gol'dberg T. I. Fomina T. V. Vetoshkina T. Yu. Dubskaya V. E. Gol'dberg M. V. Filipova |
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| Affiliation: | (1) Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Siberian, USSR |
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| Abstract: | Experiments performed on rats have shown that a single intravenous injection of the antitumor preparations platidiam and pharmorubicine in the maximum tolerated dose cause morphological changes in the liver which are preserved for 3 months after platidiam and for 6 moths after pharmorubicine. Instability of reparative processes in the liver was revealed when the rats were poisoned with CCl4, 1, 3, and 6 months after administration of the cytostatics. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 561–564, November, 1998 |
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| Keywords: | liver platidiam pharmorubicine CCl 4-induced hepatitis |
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