| 卡前列素栓配伍米非司酮终止早孕的临床多中心比较性研究 |
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| 引用本文： | 杜明昆 卢玉兰. 卡前列素栓配伍米非司酮终止早孕的临床多中心比较性研究[J]. 生殖与避孕, 1993, 13(6): 436-441 |
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| 作者姓名： | 杜明昆 卢玉兰 |
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| 作者单位： | 上海医科大学妇产科医院(杜明昆)，上海国际和平妇幼保健院(卢玉兰)，上海第一妇婴保健院(吴学浙)，中山医院(李红)，瑞金医院(金毓翠) |
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| 摘 要： | 450例闭经49天以内的早孕妇女,随机分成两组。试验组给国产米非司酮25mg,每日口服2次,连服3天(总剂量150mg),第4天经阴道给卡前列素栓1mg,共300例。对照组给予同样剂量的国产米非司酮后经阴道给PG 05 1mg,共150例。结果:前者的完全流产率为89%,后者为94%,两组抗早孕效果无统计学差异(P>0.05)。然而前者作用缓慢,腹痛、腹泻、呕吐等副反应较后者明显减少、减轻(P<0.001)。而后者作用快,孕囊排出时间短,6h 内排出的比例高(P<0.05)。
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| 关 键 词： | 卡前列素栓 PG 05 米非司酮 抗早孕 |
The Use of Carboprost Suppository with Mifepristone for the Termination of Early Pregnancy—A Comparative Study |
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| Du Ming-kun et al. The Use of Carboprost Suppository with Mifepristone for the Termination of Early Pregnancy—A Comparative Study[J]. Reproduction and Contraception, 1993, 13(6): 436-441 |
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| Authors: | Du Ming-kun et al |
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| Abstract: | 450 women of early pregnancy(amenorrhea≤49 days)were ramdomly treated with Mifepristone 25mg tiwce daily for 3 days,combined with a suppository of lmg Carboprost(300 cases),or a suppository of lmg PG05(150 cases)on the 4th day.Results showed thatcomplete abortion rates were 89.0% and 94.0%,respectively.There was no statisticalsignificance for them(P>0.05).However,side effects such as abdominal pain,diarrhea,andvomiting,occurred significantly the PG05 suppository group than in Carboprost suppository group(p<0.001).It was concluded that the combination of Mffepristone with a single suppository ofCarboprost or PG 05 was effective in early pregnancy iermination.Side effects in Carboprostsuppository group were milder than those in PG05 group,but the effect in PG05 suppositorygroup was more rapid than in Carboprost suppository group. |
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| Keywords: | Carboprost suppository PG05 Mifepristone Induced abortion |
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