Biosynthesis of benastatin A. |
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| Authors: | T Aoyama H Naganawa Y Muraoka T Aoyagi T Takeuchi |
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| Affiliation: | Institute of Microbial Chemistry, Tokyo, Japan. |
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| Abstract: | The biosynthesis of benastatin A, produced by Streptomyces sp. MI384-DF12, has been studied by feeding experiments with 14C- and 13C-labeled compounds followed by measurement of radioactivity and 13C NMR analysis. The results indicate that benastatin A is derived from two methionine units and fourteen acetate units, condensed in the "head-to-tail" fashion of typical polyketide biosynthesis. |
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