| MMP-9对脑出血损伤实验研究 |
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| 引用本文： | 聂本刚,喻明,李小刚,杨小芳.MMP-9对脑出血损伤实验研究[J].西部医学,2007,19(5):767-769. |
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| 作者姓名： | 聂本刚 喻明 李小刚 杨小芳 |
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| 作者单位： | 1. 遂宁市人民医院神经内科,四川,遂宁,6290001
2. 泸州医学院附属医院神经内科,四川,泸州,6460002 |
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| 基金项目： | 四川省卫生厅重点建设基金项目(No.050082) |
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| 摘 要： | 目的观察大鼠脑出血(ICH)后基质金属蛋白酶-9(MMP-9)蛋白动态表达及其与血肿周围脑组织含水量的关系。方法将雌雄各半的Wistar大鼠170只随机分为3组:正常对照组、假手术组、ICH组。每组均观察手术后6h、12h、24h、48h、72h、120h、7d、15d八个时间点,测定血肿周围脑组织含水量、MMP-9蛋白表达。结果ICH后MMP-9蛋白表达在24h~48h达高峰,与对照组相比,差异有统计学意义,与血肿周围脑组织含水量呈正相关(r=0.949,P<0.01)。结论大鼠ICH后MMP-9蛋白的表达是ICH后脑水肿形成主要因素。
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| 关 键 词： | 基质金属蛋白酶-9 脑出血 脑水肿 |
| 文章编号： | 1672-3511（2007）04-0767-03 |
| 修稿时间： | 2007-02-14 |
Relationship between MP-9 and intracerebral hemorrhage injury |
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| NIE Beng-gang ,YU Ming , LI Xiao-gang , et al.Relationship between MP-9 and intracerebral hemorrhage injury[J].Medical Journal of West China,2007,19(5):767-769. |
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| Authors: | NIE Beng-gang YU Ming LI Xiao-gang |
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| Abstract: | Objective To observe the relationship between the changes of contents of matrix metalloproteinase-9(MMP-9) protein and water contents in perihematoma in rats with intracerebral hemorrhage.Methods 170 Wistar rats of half male and half female were assigned randomly to three groups: normal control group,sham operation group,and ICH group.The water contents in perihematoma and the expression of MMP-9 protein were measured respectively at 8 time points of 6h,12h,24h,48h,72h,120h,7d,and 15d after operation in every group.Results The contents of MMP-9 protein at 24h-48h were higher in comparison with other time points and the control group(P<0.01).The changes of the contents of MMP-9 protein were positively correlated with water contents in perihematoma(r=0.949,P<0.01) after ICH.Conclusion The expression of MMP-9 protein is an important factor relating to brain edema after ICH. |
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| Keywords: | Matrix metalloproteinase-9 Intracerebral hemorrhage Brain edema |
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