Cold agglutinins in rhesus macaques infected with simian immunodeficiency virus (SIV) |
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Authors: | C P Mandell and A Spinner |
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Institution: | (1) Department of Medical Pathology, School of Medicine, University of California, 95616 Davis, CA, USA;(2) California Regional Primate Research Center, Davis, California, USA |
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Abstract: | Cold agglutinins are uncommon autoimmune phenomena associated with mycoplasma pneumonia, viral infections, lymphoproliferative
neoplasia and recently, acquired immunodeficiency syndrome (AIDS) in human beings. Six rhesus macaques infected with pathogenic
isolates of simian immunodeficiency virus (SIV) developed cold agglutinins late in the course of viral infection in association
with hyperproteinaemia, hyperglobulinaemia and thrombocytopenia. Cold agglutinin titres ranged from 1:1024 to 1:8192. The
development of cold agglutinins in SIV-infected rhesus macaques may be another manifestation of immune dysfunction in this
non-human primate model of AIDS. |
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Keywords: | AIDS Autoantibodies Immune-mediated disease Spurious macrocytosis Thrombocytopenia |
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