广西省百色市地中海贫血干预模式初探

目的:初步探讨广西省百色市地中海贫血干预模式。方法:在干预区进行地中海贫血的宣传、遗传咨询活动,提供地中海贫血筛查和产前诊断服务,并在干预前后对调查对象进行问卷调查。结果:调查对象的地贫基本知识及态度的基线答对率为(44±6.7)％(10％～92％),干预后答对率为(81±5.8)％(62％～96％),干预前后有显著性差异(P<0.01)。干预组进行地贫筛查例数为630/700(90％)。干预后进行产前诊断25例(年均8.33例),比干预前年均增加4例(P<0.05)。干预后促进的产前诊断比干预前提高了37％,每2.7例产前诊断就有1例是由于预措施促成,并避免了4例重型地贫儿的出生。结论:干预后妊娠高危胎儿孕妇进行产前诊断例数提高,干预效果明显。

Discussion on the Intervention of Thalassanemias in Baise City in Guangxi Province

Objective: To discuss the intervention of thalassanemia in Baise city. Methods: intervention strategies include the education of thalassanemia, genetic counseling, screening of thalassanemia, services of prenatal diagnosis. Self - administration questionnaires for interviewees were carried out before and after the intervention. Results: The percentage of interviewees who had correct responses and attitudes on basic knowledge of thalassanemia was 10% ~92% before education and 62% ~96% after education, respectively. There was significant difference before and after intervention(P <0. 01) . 630 cases received screening a-mong the 700 cases of the intervention group. 25 cases received prenatal diagnosis after thalassanemia intervention , and it added 4 cases than pre - education ( P < 0. 05 ) . The percentage of ones who received prenatal diagnosis improve 37% after the thalassanemia intervention, and 1 case among every 2.7 cases receiving prenatal diagnosis was achieved because of the intervention. 4 babies with severe thalassanemia were avoided. Conclusions: The number of expectant mothers receiving prenatal diagnosis is increasing after the intervention, and the intervention is effective.