| 硫酸锌对实验性心律失常的影响 |
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| 引用本文： | 马欣,李孝光. 硫酸锌对实验性心律失常的影响[J]. 中国药理学通报, 1989, 0(2) |
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| 作者姓名： | 马欣 李孝光 |
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| 作者单位： | [1]西安医科大学电生理研究室 [2]西安医科大学电生理研究室 西安 |
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| 基金项目： | 中国科学院科学基金资助的课题 |
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| 摘 要： | 用6种实验性心律失常动物模型,观察ZnSO_4的抗心律失常作用。ZnSO_4 iv10mg/kg能明显对抗乌头碱和BaCl_2诱发大鼠心律失常,显著缩短CHCl_3-肾上腺素引起家兔心律失常的持续时间.ZnS0_4ip20μg/10g可降低CHCl_3引起小鼠室颤率。但ZnSO_4不能降低CaCl_2引起大鼠室颤率,减少哇巴因引起室性早搏和心室颤动的阈剂量和致死量。
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| 关 键 词： | ZnSO_4 心律失常 抗心律失常 乌头碱 CHCl_3 |
EFFECTS OF ZnSO_4 ON EXPERIMENTAL ARRHYTHMIAS |
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| Abstract: | The antiarrhythmic actions of ZnSO4 (Zinc) were studied in ex-perimental arrhythmias models. ZnSO4 10mg/kg(iv) significantly coun-teracted the arrhythmias, induced by aconitine or BaCl2 rats.It was shown to shorten the duration of arrhythmias induced by chloroform-epinephrine in rabbits. In mice, ZnSO4 20 μg/10g(ip) decreased the incidence of ventricular fibrillationbychloroform. However, ZnSO4 did not decrease the incidence of CaCl2-induced , venticular fibrillation, the threshold and lethal doseofouabain in producing ventricular permature beats, ventricular fibrillation in guinea pigs. |
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| Keywords: | ZnSO_4 Arrhythmias Antiarrhythmia Aconitine Chloroform |
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