| 急性淋巴细胞白血病化疗及复发后细胞免疫表型变化分析 |
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| 引用本文： | 周越,张明珙,宋素琴,宋强,李杰.急性淋巴细胞白血病化疗及复发后细胞免疫表型变化分析[J].山东大学学报(医学版),1997(1). |
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| 作者姓名： | 周越 张明珙 宋素琴 宋强 李杰 |
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| 作者单位： | 山东医科大学附属医院血液病研究室 |
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| 摘 要： | 利用单克隆抗体及ＡＰＡＡＰ技术，发现急性淋巴细胞白血病细胞免疫表型在复发或化疗后有明显变化，表现为某些抗原的获得或丢失。复发１１例中８例细胞表型有变化，分别获得ＣＤ３８、ＣＤ９、ＣＤ７、ＣＤ１０、ＤＲ抗原，其中２例ＣＤ５等抗原丢失。化疗后７例中２例表面抗原标记消失，临床完全缓解，３例分别有ＣＤ１９、ＣＤ５、ＣＤ９抗原的获得或丢失，１例化疗前后无标记，化疗后出现ＣＤ１９、ＣＤ２０。
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| 关 键 词： | 抗体，单克隆 白血病，淋巴母细胞型 免疫表型 |
ALTERATIONS OF BLAST CELL PHENOTYPE AT RELAPSE AND AFTER CHEMOTHERAPY IN LYMPHOCYTIC LEUKEMIA |
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| Zhou Yue Zhang Minggong Song Suqing,et al.ALTERATIONS OF BLAST CELL PHENOTYPE AT RELAPSE AND AFTER CHEMOTHERAPY IN LYMPHOCYTIC LEUKEMIA[J].Journal of Shandong University:Health Sciences,1997(1). |
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| Authors: | Zhou Yue Zhang Minggong Song Suqing |
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| Abstract: | To investigate phenotype alterations in lymphocytic leukemia,blast cell immunologic markers were analyzed with monoclonal antibodies and APAAP technique at first relapse or pre and post chemotherapy.Positive shifts exactly in some cases,some new markers occured and some old markers disappered.In 11 relapsed cases,8 gained CD 38 ,CD 9,CD 7,CD 10 ,DR,respectively,2 lost CD 5. In 7 treated cases,2 disappeared all leukemic markers and got CR.3 gained or lost CD 19 ,CD 5,CD 9,respectively after chemotherapy.One case with non marker at pre chemotherapy become CD 19 CD 20 positive after chemotherapy. |
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| Keywords: | Antibodies monoclonal Leukemia lymphocytic Phenotype |
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