体外受精—胚胎移植中影响临床妊娠的因素

目的 探讨体外受精－胚胎移植（ＩＶＦ－ＥＴ）中影响临床妊娠率的因素。方法 对１９９２年至１９９５年１１月因双侧输卵管梗阻而行ＩＶＦ－ＥＴ的５５９个周期的资料进行回顾性分析,应用计算机ＳＰＳＳ－ＰＣ－Ｖ３．０系统,进行单因素变异方差分析。 ５５９个周期总临床妊娠率为２１．６％。结核性输卵管梗阻占２８．４％,继发不孕中３４．９％有人工流产史。环境改变、阻塞原因不同及过去子宫内妊娠,不影响ＩＶＦ－ＥＴ成

Factors affecting the clinical pregnancy rate in an in vitro fertilization and embryo transfer program

OBJECTIVE: To analyze the various factors in an in vitro fertilization and embryo transfer (IVF-ET) program which may affect the clinical pregnacy rate. METHODS: A retrospective study was done on 559 IVF-ET cycles from 1992-Nov. 1995. The indication for treatment was bilateral tubal blockage. The chi 2 analysis of single factor variants with SPSS-PC + V3.0 was used for statistics. RESULTS: The overall clinical pregnancy rate in 559 cycles was 21.6%. The cause of tubal blockage due to tuberculoses consisted of 28.4%, and 34.9% of secondary sterility had the history of artificial abortion. The changes of environment, the different causes of tubal blockage, the history of previous intrauterine pregnancy did not affect the clinical pregnancy rate. When the number of embryos transferred increased to 5, the clinical pregnancy rate was highest 32.5%. The cumulative embryo score or embryo quality was related significantly with clinical pregnancy rate. CONCLUSIONS: The number and quality of embryos transferred are important factors affecting the clinical pregnancy rate. However, measures to prevent high-order multiple pregnancy and studies on the survival potential of embryos besides their morphology should be emphasized.