Catecholamine uptake sites in the rat heart after 6-hydroxydopamine treatment and in a genetically hypertensive strain |
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| Authors: | Patrick J. Salt Leslie L. Iversen |
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| Affiliation: | (1) Department of Pharmacology, University of Cambridge, Cambridge, England;(2) Present address: Medical School, The Middlesex Hospital, W. 1 London, England;(3) Rheumatology Research Department Arthur Stanley House, The Middlesex Hospital Medical School, W1P 9PG London, England |
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| Abstract: | Summary Uptake of 3H-NA was measured in hearts from genetically hypertensive and  chemically sympathectomised rats. The endogenous cardiac NA content and NA uptake1 were depressed in genetically hypertensive animals, although NA uptake2 per heart was normal. After treatment of normal rats with 6-hydroxydopamine (chemical sympathectomy) endogenous cardiac NA, uptake1 and uptake2 were markedly lowered. Uptake2 inhibition by corticosterone varied in the two conditions tested, whereas no change in the potency of clonidine was detected in the genetically hypertensive rats. |
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| Keywords: | Noradrenaline Uptake 6-Hydroxydopamine Hypertension Clonidine Corticosterone |
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