康复新对单纯皮肤创面和合并全身放射损伤时的促愈作用

目的：了解放射损伤后创面愈合速度和创面牵张强度的变化及康复新的促愈作用。方法：采用Ｗｉｓｔａｒ大鼠全身５Ｇｙ＾６０Ｃｏγ线射复合背部两个圆形的全层皮肤创伤模型，观察康复新对伤后创面愈合速度，创面平均愈合时间和创面张强度的影响。

Study of the heal-promoting effect of kangfuxin on full thickness dermal wound and dermal wound complicated with systemic gamma ray radiation in rats

Objective:To study the effects of 5 Gy whole body irradiation on wound contraction and wound tensile strength and to observe the heal promoting effects of Kangfuxin on simple dermal wound and compound wound. Methods:2 full thickness dermal wounds with a diameter of 1.6 cm were inflicted on the back of the rats. In the compound wound group,prior to the infliction of dermal wound,the rat received 5 Gy gamma ray radiation from a 60 Co source. Then the therapeutic effect of Kangfuxin on the wound contraction,average wound healing time and wound tensile strength was observed. Results: After gamma ray irradiation,wound contraction and average wound healing time were significantly delayed and wound tensile strength decreased. Kangfuxin accelerated the wound contract,decreased the average wound healing time and improved wound tensile strength in a dosage effect relationship. The heal promoting effect of Kangfuxin was more obvious in irradiated wounds than in simple wound. Conclusion: Whole body irradiation of gamma rays delays the healing of dermal wound. The heal promoting effect of Kangfuxin is more obvious in the compound wound(irradiated with gamma rays) than in the simple wound. A daily dosage of 5 mg of Kangfuxin is advised for the management of skin lesions.