胃癌组织nm23和c-erbB_2癌基因蛋白表达与根治术后再发癌的关系

目的探讨ｎｍ２３和ｃｅｒｂＢ２癌基因蛋白表达与胃癌根治术后再发癌发生的关系．方法采用免疫组化ＳＰ法检测６４例胃癌中ｎｍ２３和ｃｅｒｂＢ２的表达，并结合内镜及随访资料进行分析．结果胃癌ｎｍ２３低表达率及ｃｅｒｂＢ２阳性率在淋巴结转移组及术后３ａ内有再发癌组明显增高，ｎｍ２３低表达率及ｃｅｒｂＢ２阳性率：有淋巴结转移组为６８９％（３１／４５）和４２２％（１９／４５）；无淋巴结转移组为３６８％（７／１９）和１５８％（３／１９）；术后３ａ内再发癌组为８１０％（１７／２１）和５２４％（１１／２１）；术后３ａ以上无再发癌组为４８８％（２１／４３）和２２６％（１１／４３）（Ｐ＜００５）．而且ｎｍ２３低表达与肿瘤浸润程度有关，浸至浆膜及周围脏器组ｎｍ２３低表达率为７８６％（２２／２８）；浸至粘膜及粘膜下组者为４００％（６／１５）（Ｐ＜００５）．结论胃癌ｎｍ２３低表达和ｃｅｒｂＢ２阳性表达者具有较强的浸润、转移能力，且术后易发生再发癌，二者的表达变化对判断胃癌术后再发癌的发生及预后有重要意义

nm23 and c erbB 2 proto oncogene protein expression in gastric recurrent carcinoma

AIM To study the relationship between nm23 and c erbB 2 proto oncogene protein expression in gastric cancers and recurrent carcinoma. METHODS The expressions of nm23 and c erbB 2 in 64 cases of gastric cancer were examined by S P immunohistochemical method, and analyzed in combination with gastroscopy and follow up materials. RESULTS nm23 low expression rate and c erbB 2 positive rate of the groups with lymph node metastasis or recurrent cancer were obviously higher than the groups without metastasis or recurrence. nm23 low expression rate and c erbB 2 positive rate were 68 9%(31/45) and 42 2%(19/45) in gastric carcinoma with metastasis to lymph nodes; 36 8%(7/19) and 15 8%(3/19) without metastasis; 81 0(17/21) and 52 4%(11/21) for patients with recurrent cancer within 3 years after operation; 48 8%(21/43) and 22 6%(11/43) without recurrent cancer over 3 years, P <0 05. And nm23 low expression was remarkably related to the depth of cancer invasion. nm23 low expression rate was 78 6%(22/28) in the carcinoma invading serosa and peripheral organs, and 40 0%(6/15) invading mucosa and submucosa, P <0 05. CONCLUSION nm23 low expression and c erbB 2 positive expression might play an important role in lymph node metastasis and invasion of gastric cancer, and recurrent cancer after operation. The detection of nm23 and c erbB 2 is important for prediction of recurrent cancer and prognosis.