多不饱和脂肪酸在骨质疏松症中的研究进展

多不饱和脂肪酸（PUFA）,是指碳氢链有两个或两个以上不饱和键的脂肪酸,通常分为n-3PUFA和n-6PUFA两种。骨质疏松症（OP）是以骨量减少、骨组织显微结构退化为特征,以致骨的脆性增高及骨折危险性增加的一种全身性骨病。已知遗传、年龄、内分泌、饮食等因素均参与OP的发病,但确切的病因及发病机制尚未明了。近年不少研究发现饮食中的PUFA对骨健康存在重要影响,本文特就PUFA在OP发病机制及治疗中的研究进展作一综述。

Advances on Roles of Polyunsaturated Fatty Acids in Osteoporosis

Polyunsaturated fatty acids（PUFA） are fatty acids that contain two or more double bonds in their backbone,usually divided into n-3PUFA and n-6PUFA.Osteoporosis（OP） is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue,with a consequent increase in bone fragility and susceptibility to fracture risk.The pathogenesis of OP is still unknown although the factors of genetic,age,endocrine and diet were reported to be heavily involved in OP development.Recently more and more researches had found that PUFA in the diet played important roles on the bone health.This paper aims to review the recent advances of PUFA in the pathogenesis and treating of OP.