垂体后叶素与奥曲肽治疗肝硬化上消化道出血的临床研究

目的探讨垂体后叶素与奥曲肽联合治疗对肝硬化上消化道出血的止血效果。方法回顾性分析了我院收治的85例肝硬化上消化道出血患者的临床资料,对照组42例采用常规止血治疗,观察组43例采用常规止血治疗加用垂体后叶素与奥曲肽联合治疗,比较两组的疗效、不良反应发生率、显效时间与止血时间。结果观察组总有效率为95.35%,对照组为71.43%,两组比较,差异有统计学意义（P〈0.05）;观察组不良反应发生率为13.95%,对照组患者不良反应发生率为14.29%,两组比较,差异无统计学意义（P〉0.05）;观察组显效时间为（5.64±1.34）小时、止血时间为（10.85±2.29）小时,对照组显效时间为（9.34±1.98）小时、止血时间为（14.61±2.75）小时,两组比较,差异有统计学意义（P〈0.05）。结论垂体后叶素与奥曲肽联合治疗肝硬化上消化道出血的疗效好、显效快、不良反应少。

Pituitary Vasopressin and Octreotide in the Treatment of Upper Gastrointestinal Hemorrhage Caused by Liver Cirrhosis

Objective To investigate the hemostatic effect of pituitary vasopressin combined with octreotide in the treatment of upper gastrointestinal hemorrhage caused by liver cirrhosis.Methods The clinical data of 87 patients with upper gastrointestinal hemorrhage caused by liver cirrhosis in our hospital were analyzed retrospectively.The control group（42 cases） received conventional hemostatic therapy,while the observation group（43 cases） received the treatment of pituitary vasopressin combined with octreotide plus conventional hemostatic therapy.The curative effect,incidence of adverse reactions,effective time and hemostatic time were compared.Results Total effective rate was 95.35% in the observation group and 71.43% in the control group,the difference between two groups was statistically significant（P 0.05）.The incidence of adverse reactions was 13.95% in the observation group and 14.29% in the control group,the difference between two groups was not statistically significant（P 0.05）.The effective time and hemostatic time were（5.64 ± 1.34） hours and（10.85 ± 2.29） hours in the observation group,（9.34 ± 1.98） hours and（14.61 ± 2.75） hours in the control group respectively;the differences between two groups were statistically significant（P 0.05）.Conclusions Pituitrin combined with octreotide combination therapy in the treatment of upper gastrointestinal hemorrhage caused by liver cirrhosis has good efficacy,quick effect and few adverse reactions.