抗结核药物致高危人群肝损害临床分析

目的分析抗结核药物导致肝损害的主要因素,提供临床参考。方法对我院2011年3月至2011年10月收治的674例抗结核患者资料进行回顾性分析,总结患者出现肝损伤的例数,总结患者分析导致肝损伤的高危因素,调查内容包括性别、年龄、结核病的类型、抗结核药物疗程、并发症,结果使用SPSS18.0统计学分析。结果年龄越大、有血行播散型肺结核,其肝损害更容易发生,组间比较,P〈0.05,差异有统计学意义;用药时间长、合并肝炎患者容易发生肝损伤,差异有统计学意义,P〈0.05。结论抗结核药物发生肝损伤与年龄、并发症、治疗疗程和抗结核类型均有关系,针对此类患者需要医生积极给予保肝护肝药物。

Clinical Analysis of Anti-Tuberculosis Drugs Induced Liver Damage at High Risk

Objective To analyze the main factors for anti-TB drugs to cause liver damage,and provide clinical reference.Methods The clinical data of 674 patients with anti-TB drugs in our hospital from July 2009 to October 2011 were analyzed retrospectively.The main high risk factors to cause liver damage were summerized.The survey included gender,age,types of tuberculosis,anti-TB drug regimens,and complications.The results were analyzed by SPSS 18.0.Results Patients with higher age,and hematogenous disseminated pulmonary tuberculosis had higher incidence of liver damage,the difference was statistically significant（P 0.05）.Patients with longer duration of anti-TB drugs and hepatitis had higher incidence of liver damage,the difference was statistically significant（P 0.05）.Conclusions The occurrence of liver injury induced by anti-tuberculosis drugs is related to the age,complications,treatment regimens and the anti-TB type,so such patients require hepatoprotective drugs.