内皮细胞特异性分子与子痫前期关系的研究进展

子痫前期是一种妊娠期特有疾病,血管内皮细胞受损是目前普遍认可的主要病理生理变化之一.内皮细胞特异性分子(endocan)作为内皮功能障碍的一种新型生物标志物,在其多种生物学功能中,作为一种血管保护分子可以保护内皮免受炎症细胞的迁移和增殖等,所以在心血管系统疾病、肿瘤、脓毒症等方面被广泛研究,成为诊断及治疗疾病的有效靶点...

Research Progress on the Relationship between Endocan and Pre-Eclampsia

Pre-eclampsia is a unique disease during pregnancy,and its pathogenesis is the research focus of many scholars.Vascular endothelial cell dysfunction is one of the main pathophysiological changes generally recognized.As a new type of biomarker for endothelial dysfunction,endothelial cell-specific molecule(endocan)can protect endothelium from the migration and proliferation of inflammatory cells.Vascular system diseases,tumors,sepsis,etc.have been extensively studied and become effective targets for diagnosis and treatment of diseases.Recent studies have found that endocan is differentially expressed in the serum and placenta of patients with pre-eclampsia,suggesting that endocan may be involved in the pathogenesis of pre-eclampsia.Therefore,in-depth study of the relationship between endocan and pre-eclampsia will help reveal the pathogenesis of pre-eclampsia and provide a basis for early prevention and treatment of the disease.This article reviews the research progress of the relationship between endocan and pre-eclampsia.