生物活性因子在妊娠期高血压疾病发病机制中的作用

妊娠期高血压疾病(hypertensive disorder complicating pregnancy,HDCP)是妊娠和高血压并存的一组疾病,是严重的妊娠期并发症,病因和发病机制目前尚未完全阐明.目前研究认为内在遗传因素与外在环境因素相互作用导致胎盘缺氧缺血是HDCP发病的主要机制.胎盘缺血缺氧促进生物活性因子释...

The Role of Biologically Active Factors in the Pathogenesis of Hypertension in Pregnancy

Hypertensive disorder complicating pregnancy (HDCP) is a group of diseases that coexist with pregnancy and hypertension, and are serious complications of pregnancy. The etiology and pathogenesis have not yet been fully elucidated. Current researches believe that the interaction of internal genetic factors and external environmental factors leading to placental hypoxia-ischemia is the main mechanism of HDCP. Placental ischemia and hypoxia promote the release of biologically active factors into the maternal circulation. On the one hand, it causes vascular endothelial hyperplasia and spasm in important organs of the body (brain, kidney, liver), leading to hypertension, proteinuria, cerebral edema, eclampsia, etc. On the other hand, biologically active factors inhibit the degradation of extracellular matrix, leading to insufficient vascular remodeling ability, increasing vascular arteriosclerosis, increasing vascular resistance and aggravating placental ischemia and hypoxia, triggering HDCP cycles. There are three main biologically active factors involved in the pathogenesis of HDCP: anti-angiogenic factors, pro-angiogenic factors and pro-inflammatory factors. This article combines recent domestic and foreign literature, focusing on the role of three active factors in the pathogenesis of HDCP, and provides a solid theoretical basis for early prediction and early diagnosis of HDCP.