NLR家族Pyrin域蛋白3炎症小体与妊娠的研究进展

炎症小体是人类天然免疫系统的重要组成部分,参与包括妊娠在内的多种炎症反应,其中NLR家族Pyrin域蛋白3(NLRP3)炎症小体是目前研究最广泛的炎症小体,是宿主防御反应的重要因素,其能够对固有免疫进行调控,各种环境剌激物、多种微生物、内源性或外源性危险信号、病原体和不同的病原相关分子模式(PAMPs)/损伤相关分子模...

Research Progress of NLRP3 Inflammasome and Pregnancy

Inflammasome are an important part of the natural immune system and participate in many inflammatory reactions including pregnancy. NLRP3 inflammasome is the most widely studied inflammasome, which is an important factor of host defense response. It can regulate innate immunity, various environmental stimuli, various microorganisms, endogenous or exogenous danger signals, pathogens and different PAMPs/DAMPs can activate NLRP3 inflammasome to release cytokines,induce caspase-1 dependent apoptotic process,and participate in various inflammatory disease processes, but the regulatory mechanism is not clear. In recent years, it has been found that NLRP3 inflammasome is associated with the mechanism of delivery, and the NLRP3-mediated immune response is initiated during pregnancy. The abnormal expression of NLRP3 inflammasome is associated with the development of gestational diseases such as recurrent miscarriage, premature birth, preeclampsia and gestational diabetes. This article reviews the research progress of NLRP3 inflammasome and pregnancy.